The CD57 marker is present on natural killer cells (NK) and T lymphocytes. In cases of chronic diseases such as Lyme disease the number of CD57 NK cells has been shown to be below normal. Following treatment the count can return to normal (Stricker and Winger, 2001. Immunol Letter. 76:43-48). However, the utility of this test is controversial. Marques et. al. (2009 Clin. Vaccine Immunol. 16:1249-50) reported that there was no difference between the CD57 NK cell counts among patients with Lyme disease and normal controls. This test measures only the CD57 NK cells and may be useful for patients with known Lyme disease who present with chronic symptoms. If the count is low, the cause of the symptoms may be from Borrelia burgdorferi. If the count is normal, the cause may still be from Lyme disease, or it may be from some other agent.
CD57 NK Cell Test
Test Number 295
CPT Code 86356
Methodology: Flow Cytometry
- Collection and Shipping Instructions: See whole blood collection procedure. Sample must be stored and sent at room temperature.
- Shipping: Sample must be shipped 2 day FedEX on the same day specimen is collected.
- Sample Stability: 48 hours at ambient temperature
- Rejection Criteria refer to general collection procedure. Specimens older than 48 h Frozen/refrigerated samples will not be accepted)